Resveratrol inhibits nicotine-induced conditioned place preference in mice

Nicotine addiction leads to in a huge burden on public health and the economy worldwide. Resveratrol (3,5,4’-tetrahydroxystilbene) is most well-known polyphenolic stilbenoid. was shown exhibit positive effects numerous mechanisms that are important for drug substance addiction. Thus, this study aimed examine effect of resveratrol nicotine Intraperitoneal (i.p.) treatment with (0.5 mg/kg) significantly enhanced time spent nicotine-paired compartment. (50 75 mg/kg, i.p.) varenicline (2 co-administered during 3-day conditioning period effectively diminished acquisition nicotine-induced conditioned place preference (CPP). On other hand, administration decreased low dose (0.1 reinstatement. The results suggest inhibit reinstatement nicotine’s reward properties. displayed similar CPP phases as obtained reference varenicline. In conclusion, could be beneficial an adjuvant pharmacotherapy addiction; however, more investigation needed completely explain property.